Protein name:
Mothers against decapentaplegic homolog 7 (MAD homolog 7;Mothers against DPP homolog 7) ;
Alternative:
SMAD family member 7 (SMAD 7;Smad7) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with COPS5. Interacts with STAMBP. Interacts with NEDD4L. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation. Interacts with WWP1.
Function:
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.
Subcellular Location:
Nucleus
Cytoplasm
Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.
Protein Attributes:
50:
MFRTKRSALV | RRLWRSRAPG | GEDEEEGVGG | GGGGGGLRGE | GATDGRAYGA |
100:
GGGGAGRAGC | CLGKAVRGAK | GHHHPHPPSS | GAGAAGGAEA | DLKALTHSVL |
150:
KKLKERQLEL | LLQAVESRGG | TRTACLLLPG | RLDCRLGPGA | PASAQPAQPP |
200:
SSYSLPLLLC | KVFRWPDLRH | SSEVKRLCCC | ESYGKINPEL | VCCNPHHLSR |
250:
LCELESPPPP | YSRYPMDFLK | PTADCPDAVP | SSDETGGTNY | LAPGGLSDSQ |
300:
LLLEPGDRSH | WCVVAYWEEK | TRVGRLYCVQ | EPSLDIFYDL | PQGNGFCLGQ |
350:
LNSDNKSQLV | QKVRSKIGCG | IQLTREVDGV | WVYNRSSYPI | FIKSATLDNP |
400:
DSRTLLVHKV | FPGFSIKAFD | YEKAYSLQRP | NDHEFMQQPW | TGFTVQISFV |
426:
KGWGQCYTRQ | FISSCPCWLE | VIFNSR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Rat MAD homolog 7
ELISA Kit for Rat MAD homolog 7
ELISA Kit for Rat MAD homolog 7
CLIA Kit for Rat MAD homolog 7
CLIA Kit for Rat MAD homolog 7
CLIA Kit for Rat MAD homolog 7
Polyclonal Antibody for Rat MAD homolog 7
Polyclonal Antibody for Rat MAD homolog 7
Polyclonal Antibody for Rat MAD homolog 7
Monoclonal Antibody for Rat MAD homolog 7
Monoclonal Antibody for Rat MAD homolog 7
Monoclonal Antibody for Rat MAD homolog 7
Protein for Rat MAD homolog 7
Protein for Rat MAD homolog 7
Protein for Rat MAD homolog 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]